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Monday, May 18, 2020 | History

2 edition of Synthetic peptides in the search for B- and T-cell epitopes found in the catalog.

Synthetic peptides in the search for B- and T-cell epitopes

Synthetic peptides in the search for B- and T-cell epitopes

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Published by R.G. Landes Co. in Austin, Tex .
Written in English

    Subjects:
  • Peptides -- Immunology.,
  • Antigenic determinants.,
  • Peptides -- Synthesis.

  • Edition Notes

    Includes bibliographical references and index.

    Statement[edited by] Éva Rajnavölgyi.
    SeriesMolecular biology intelligence unit, Molecular biology intelligence unit (Unnumbered)
    ContributionsRajnavölgyi, Éva.
    Classifications
    LC ClassificationsQR186.6.P76 S97 1994
    The Physical Object
    Pagination211 p. :
    Number of Pages211
    ID Numbers
    Open LibraryOL1112575M
    ISBN 101570591601
    LC Control Number94038447

    Choice of N- and C-terminal Peptide Endings for Mapping of T Cell Epitopes. For CD4+ (helper) cells, N- and C-terminal blocked peptides can be more effective than peptides with unblocked ends when short peptides . T cell recognition of specific antigens mediates protection from pathogens and controls neoplasias, but can also cause autoimmunity. Our knowledge of T cell antigens and their implications for human Cited by:

      Peptides OM 1–14 and – are the only ones capable of inducing IL‐4 secretion. Only one peptide (OM 11–24) induces IL‐10 secretion. Those peptides recognized as both T and B cell epitopes or only T cell epitopes. The second protocol uses a decapeptide library to identify T cell peptide ligands. The mixtures of the decapeptide library are tested for their ability to induce T cell activation. Support protocols cover Cited by: 5.

    The majority of B cell epitope mapping experiments make use of linear peptide fragments from antigenic proteins. These peptides can be homologous enough to parts of the whole antigen in order to allow antibody binding. There are two pre-requisites to identifying linear B cell epitopes. The structure of T-cell epitopes. Livingstone AM, Fathman CG. We have reviewed here studies using synthetic peptides to analyze some of the properties of T-cell epitopes. Several general conclusions can be drawn. First, T-cell epitopes Cited by:


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Synthetic peptides in the search for B- and T-cell epitopes Download PDF EPUB FB2

(in press) 8 McDonnell, T.J., Dearie, N., Platt, M. et al. () C Synthetic peptides in the search for T- and B-cell epitopes l va Rajnav61gyi In this article, Eva Rajnav61gyi describes two aspects of the rigorous application of organic chemistry to the task of synthesizing peptides Cited by: How do B and T cells see antigen / Istvan Kurucz --B and T cells: mediators of the specific immune response --B- and T-cell receptor complex --Recognition of different antigens with similar receptors --Searching for the missing piece of the puzzle --Prediction of B- and T-cell epitopes / Ferenc Hudecz --Prediction of B-cell epitopes.

These epitopes can be used to develop more effective vaccines and identify neutralizing antibodies. We identified viral peptides with good antigen presentation scores for both human MHC-I and MHC-II alleles, and two potential neutralizing B-cell epitopes Cited by: 2.

The novel severe respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide. The present study followed computational approaches to identify B- and T-cell epitopes for spike glycoprotein of SARS-CoV-2 by its interactions with the human leukocyte antigen alleles.

We identified twenty-four peptide. The understanding of B cell and T cell specificity has been advanced significantly by the development and use of libraries composed of millions of synthetic peptides.

The use of peptide libraries has led to the identification of high-affinity ligands for both T cells Cited by: 5. The outbreak of the novel coronavirus (SARS-CoV-2) has infected thousands of people with a large number of deaths across 26 countries.

The sudden appearance of the virus leads to the limited existing therapies for SARS-CoV Therefore, vaccines and antiviral medicines are in desperate need.

This study took immune-informatics approaches to identify B- and T-cell epitopes Author: Lin Li, Ting Sun, Yufei He, Wendong Li, Yubo Fan, Jing Zhang.

Abstract. Many studies in recent years have been directed towards producing fully synthetic peptide immunogens (Francis and Clarke ; Francisthis volume) which contain the necessary B- and T-cell epitopes for immunogenicity in r, there is little doubt that carrier proteins still offer the most straightforward and convenient way of presenting poorly immunogenic peptides Cited by: 2.

Cite this chapter as: Chong P. et al. () Mapping of the immunodominant B- and T-cell epitopes of the outer membrane protein D15 of H. influenzae type b using overlapping synthetic peptides.

In: Tam J.P., Kaumaya P.T.P. (eds) Peptides Frontiers of Peptide Cited by: 2. Compared to large protein carriers, these helper peptides do not stimulate a crossreactive response because they do not carry any B-cell or CD8 T-cell epitope in their sequence [24]. For example, universal Pan HLA-DR-binding epitope (PADRE) (AKFVAAWTLKAAA) was incorporated into several experimental vaccines to stimulate an antibody-mediated response against B-cell epitopes.

Mobilizing peptides in immunity. Defining useful B- and T-cell epitopes (that are recognized by B cells and T cells) has not been straightforward, and Flower argues that the obstacle. We report the development of two models for synthetic hepatitis B vaccines.

The models were based on the multiple antigen peptide (MAP) system and contained the relevant B- and T-cell epitopes without any macromolecular carrier. Two peptides, representing the a determinant of the S region (S protein) of hepatitis B surface antigen, a dominant serotype of hepatitis B Cited by:   Mapping of T-cell epitopes.

This server allows searching of peptide in Bcipep against MHCBN database. The MHCBN database provides information about components of cell-mediated immunity like MHC binders/non-binders, T-cell epitopes and TAP binders [].The peptides related to cell-mediated immunity can be mapped on resultant B-cell epitopes obtained from keyword/peptide search Cited by: The peptides related to cell-mediated immunity can be mapped on resultant B-cell epitopes obtained from keyword/peptide search by clicking on 'Peptide Sequence' field (Figures (Figures2b 2b and and3b).

3b). Thus, the server is useful in identifying the potential B-cell epitopes having T-cell epitopes Cited by: Many peptides contain B-cell epitopes, but not T-cell epitopes. In immunological terms, these peptides and other such molecules are called haptens.

Coupling these molecules to a large carrier protein containing T-cell epitopes allows the induction of a B-cell response to the entire immunogen, including the peptide Cited by: CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): The immunogenicity ofchimeric peptides produced by collinear synthesis to contain both T and B cell epitopes from the.

In humans, professional antigen-presenting cells are specialized to present MHC class II peptides, whereas most nucleated somatic cells present MHC class I peptides. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length, whereas MHC class II molecules present longer peptides, amino acids.

The precise location of B and T cell epitopes have been established in a peptide containing the major immunogenic site (residues ) of FMDV strain 01 Campos (01C) VP1. The peptide Cited by:   T Cell Epitope Mapping of Major Allergens.

T cell epitope peptide therapies rely on the identification of immunodominant CD4 + T cell epitopes within major, clinically relevant allergens. Molecular cloning, characterization and sequencing of allergens allow the synthesis of nested sets of overlapping peptides Cited by: T-cell epitopes are defined as peptide sequences which, in association with proteins on antigen-presenting cells (APC), are required for recognition by specific T-cells.

PepSets peptide libraries make it possible to rapidly identify the epitopes. This chapter describes a methodology for elucidating immunogenic epitopes stimulatory for CD4 + T-cell clones ().The methodology makes use of synthetic peptide libraries and must be regarded as an alternative to other approaches, such as peptide Cited by: 1.

Synthetic peptides can act as epitopes in the preparation of vaccines. Given their small size and poor immunogenicity, these peptides need to be attached to large carriers, such as proteins, synthetic polymers, and liposomes.

Five peptides previously examined as probable B-epitopes were used as well. All the peptides were tested for their ability to stimulate proliferation of lymph node T-cells primed with synthetic peptides. Almost all predicted T-epitopes affected the T-cell proliferation.

None of the peptides Cited by: 9.The immunogenicity of chimeric peptides produced by collinear synthesis to contain both T and B cell epitopes from the fusion protein and the haemagglutinin of measles virus was studied in mice.

The T Cited by: